For Physicians
Cancer
For further information, please refer to the following scientific papers.
Nature Review Cancer / 2018
Fasting and cancer: molecular mechanisms and clinical application.
Stephan P. Bauersfeld1, Christian S. Kessler1,2, Manfred Wischnewsky3, Annette Jaensch2, Nico Steckhan1, Rainer Stange1,2, Barbara Kunz2, Barbara Brückner4, Jalid Sehouli5 and Andreas Michalsen1,2
JOP. Journal of the Pancreas / 2018
Long-Term Outcomes of the Treatment of Unresectable (StageIII- IV) Ductal Pancreatic Adenocarcinoma Using Metabolically Supported Chemotherapy (MSCT): A Retrospective Study
CELL PRESS / 2018
Starvation, Stress Resistance, and Cancer
SCIENTIFIC REPORTS / 2017
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice
PLOS|BIOLOGY / 2017
ELSEVIER / 2017
Protective effects of short-term dietary restriction in surgical stress and chemotherapy
SCIENTIFIC REPORTS / 2017
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice
AACR / 2016
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions
BIOMED CENTRAL / 2016
Safety and feasibility of fasting in combination with platinum based chemotherapy
CELL PRESS / 2016
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
ELSEVIER / 2016
Growth factors, aging and age-related diseases
BMC CANCER / 2015
The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study
Stefanie de Groot1, Maaike PG Vreeswijk2, Marij JP Welters1, Gido Gravesteijn2, Jan JWA Boei2, Anouk Jochems1, Daniel Houtsma3, Hein Putter4, Jacobus JM van der Hoeven1, Johan WR Nortier1, Hanno Pijl5 and Judith R Kroep1
IMPACT JOURNALS / 2015
Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition
IMPACT JOURNALS / 2015
Fasting induces anti-warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
ELSEVIER / 2013
Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression
DISCOVER / 2013
A small group of Ecuadorians with rare genetic disorder could hold a key to cancer and other age-related illness.
NATIONAL INSTITUTE OF HEALTH / 2013
Aging, Nutrient Signaling, Hematopoietic Senescence, and Cancer
SCIENCE TRANSLATIONAL MEDICINE / 2012
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
ELSEVIER / 2012
Starvation, detoxification, and multi drug resistance in cancer therapy
PLOS / 2012
Fasting Enhances the Response of Glioma to Chemo and Radiotherapy
C Lee and VD Longo / 2011
Fasting vs dietary restriction in cellular protection and cancer treatment:from model organisms to patients
CANCER RESEARCH / 2010
Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fastingand Improve Chemotherapeutic Index
IMPACT AGING / 2009
Fasting and cancer treatment in humans: A case series report
PERSPECTIVES / 2008
Turning anti aging genes against cancer
ELSEVIER / 2007
A simple model system for age-dependent DNA damage and cancer
Neurodegenerative Diseases
For further information, please refer to the following scientific papers.
THE JOURNAL OF NEUROSCIENCE / 2017
Behavioral/CognitiveBrain Structure and Function Associated with YoungerAdults in Growth Hormone Receptor-Deficient Human
CELL PRESS / 2016
A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple SclerosisSymptoms
CELL PRESS / 2016
AGING CELL / 2013
Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer’s disease mouse model
AGING CELL / 2013
The Scientific World JOURNAL / 2010
Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Non dividing Cells: from Yeast to the Mammalian Brain
NEUROENDOCRINOLOGY / 2009
Progesterone Influence on Neurite Outgrowth Involves Microglia
CELL PRESS / 2008
SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
ELSEVIER / 2004
Progressive changes in regulation of apolipoproteins E and J in glial cultures during postnatal development and aging
ELSEVIER / 2004
Reversible age impairments in neurite outgrowth by manipulations of astrocytic GFAP
THE JOURNAL OF NEUROSCIENCE / 2002
Peroxynitrite Mediates Neurotoxicity of Amyloid-Peptide1–42- andLipopolysaccharide-Activated Microglia
ENDOCRINOLOGY / 2002
Estradiol (E2) Enhances Neurite Outgrowth byRepressing Glial Fibrillary Acidic Protein Expression and Reorganizing Laminin
AMERICAN MEDICAL ASSOCIATION / 2002
Genetics of Aging and Diseases
JOURNAL OF NEUROCHEMISTRY / 2000
Reversible Inactivation of Superoxide-Sensitive Aconitase inAb1–42-Treated Neuronal Cell Lines
EXPERIMENTAL NEUROLOGY / 1999
Variations of Synaptotagmin I, Synaptotagmin IV, and SynaptophysinmRNA Levels in Rat Hippocampus during the Estrous Cycle
Autoimmune diseases
For further information, please refer to the following scientific papers.
Nature Review Cancer / 2018
Fasting and cancer: molecular mechanisms and clinical application.
Stephan P. Bauersfeld1, Christian S. Kessler1,2, Manfred Wischnewsky3, Annette Jaensch2, Nico Steckhan1, Rainer Stange1,2, Barbara Kunz2, Barbara Brückner4, Jalid Sehouli5 and Andreas Michalsen1,2
JOP. Journal of the Pancreas / 2018
Long-Term Outcomes of the Treatment of Unresectable (StageIII- IV) Ductal Pancreatic Adenocarcinoma Using Metabolically Supported Chemotherapy (MSCT): A Retrospective Study
CELL PRESS / 2018
Starvation, Stress Resistance, and Cancer
SCIENTIFIC REPORTS / 2017
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice
PLOS|BIOLOGY / 2017
ELSEVIER / 2017
Protective effects of short-term dietary restriction in surgical stress and chemotherapy
SCIENTIFIC REPORTS / 2017
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice
AACR / 2016
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions
BIOMED CENTRAL / 2016
Safety and feasibility of fasting in combination with platinum based chemotherapy
CELL PRESS / 2016
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
ELSEVIER / 2016
Growth factors, aging and age-related diseases
BMC CANCER / 2015
The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study
Stefanie de Groot1, Maaike PG Vreeswijk2, Marij JP Welters1, Gido Gravesteijn2, Jan JWA Boei2, Anouk Jochems1, Daniel Houtsma3, Hein Putter4, Jacobus JM van der Hoeven1, Johan WR Nortier1, Hanno Pijl5 and Judith R Kroep1
IMPACT JOURNALS / 2015
Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition
IMPACT JOURNALS / 2015
Fasting induces anti-warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
ELSEVIER / 2013
Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression
DISCOVER / 2013
A small group of Ecuadorians with rare genetic disorder could hold a key to cancer and other age-related illness.
NATIONAL INSTITUTE OF HEALTH / 2013
Aging, Nutrient Signaling, Hematopoietic Senescence, and Cancer
SCIENCE TRANSLATIONAL MEDICINE / 2012
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy
ELSEVIER / 2012
Starvation, detoxification, and multi drug resistance in cancer therapy
PLOS / 2012
Fasting Enhances the Response of Glioma to Chemo and Radiotherapy
C Lee and VD Longo / 2011
Fasting vs dietary restriction in cellular protection and cancer treatment:from model organisms to patients
CANCER RESEARCH / 2010
Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fastingand Improve Chemotherapeutic Index
IMPACT AGING / 2009
Fasting and cancer treatment in humans: A case series report
PERSPECTIVES / 2008
Turning anti aging genes against cancer
ELSEVIER / 2007
A simple model system for age-dependent DNA damage and cancer
Cardiovascular diseases
For further information, please refer to the following scientific papers.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY / 2017
Effects of Sodium Reduction and the DASH Diet in Relation toBaseline Blood Pressure
2016
Dietary Interventions, Cardiovascular Aging, and DiseaseAnimal Models and Human Studies
JAMA / 2016
Association of Animal and Plant Protein IntakeWith All-Cause and Cause-Specific Mortality
AMERICAN HEART ASSOCIATION / 2012
Growth Factors, Nutrient Signaling, and Cardiovascular Aging
Diabetes & Obesity
For further information, please refer to the following scientific papers.
CELL / 2017
Fasting-Mimicking Diet Promotes Ngn3-Drivenb-Cell Regeneration to Reverse Diabetes
SCIENCE TRANSLATIONAL MEDICINE / 2011
Growth Hormone Receptor Deficiency Is Associatedwith a Major Reduction in Pro-Aging Signaling,Cancer, and Diabetes in Humans
Scientific Articles
For further information, please refer to the following scientific papers.
Starvation, Stress Resistance, and Cancer – Cell Press 2018 PDF
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer
and Chemotoxic Resistance in Aged Mice – Scientific Reports 2017 PDFFasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy – Plos 2017 PDF
Protective effects of short-term dietary restriction in surgical stress and chemotherapy – Elsevier 2017 PDF
Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions – American Association for Cancer Research 2016 PDF
Safety and feasibility of fasting in combination with platinum-based chemotherapy – BioMed Central 2016 PDF
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity – Cancer Cell 2016 PDF
Fasting and Caloric Restriction in Cancer Prevention and Treatment – 2016 PDF
Growth factors, aging and age-related diseases – Elsevier 2016 PDF
Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition – Oncotarget 2015 PDF
Fasting induces anti-warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models – Oncotarget 2015 PDF
Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression – Elsevier 2013 PDF
A small group of Ecuadorians with a rare genetic disorder could hold a key to cancer and other age-related illness – Discover 2013 PDF
Aging, Nutrient Signaling, Hematopoietic Senescence, and Cancer – 2013 PDF
Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy – Science Translational Medicines 2012 PDF
Starvation, detoxification, and multi-drug resistance in cancer therapy – Elsevier 2012 PDF
Fasting Enhances the Response of Glioma to Chemo- and Radiotherapy – Plos 2012 PDF
Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients – NPG 2011 PDF
Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model – Jove 2011 PDF
Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index – Cancer Research 2010 PDF
Fasting and cancer treatment in humans: A case series report – Impact Aging 2009 PDF
Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy – PNAS PDF
Turning anti-ageing genes against cancer – Nature Reviews 2008 PDF
Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system – The Journal of Cell Biology 2008 PDF
A simple model system for age-dependent DNA damage and cancer – Elsevier 2007 PDF
Contact us
European Longevity Institute at Fondazione Valter Longo
Via Borgogna, 9, 20122 Milano | Tel. 02.25138307 | info@europeanlongevityinstitute.org